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. 2018 Nov 27;7(23):e009559. doi: 10.1161/JAHA.118.009559

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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CRT (cardiac resynchronization therapy) programming based on 12‐lead ECG optimization. Patients receiving CRT 2007–2013 did not undergo 12‐lead ECG optimization of CRT settings, and most (89%) patients were programmed to standard CRT settings of simultaneous biventricular pacing. Conversely, patients implanted 2014–2017 were optimized 1 week post‐CRT with 12‐lead ECG to promote wavefront fusion. ECG optimized settings were often (73%) nonstandard, utilizing left ventricular (LV)‐only pacing appropriately timed to native conduction or sequential biventricular pacing. ACRT, adaptive CRT; RV, right ventricular; VV, ventricular‐ventricular.