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. 2018 Nov 27;7(23):e009559. doi: 10.1161/JAHA.118.009559

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Changes in echocardiographic response based on delayed enhancement (DE) categorization. The change in ejection fraction (EF) 1‐year post‐CRT (cardiac resynchronization therapy) was not altered by CRT optimization in patients without DE. However, patients with DE had improved echocardiographic outcomes following 12‐lead ECG optimization of settings for wavefront fusion. Patients with midwall stripe improved EF from 2±9 to 12±12 units (P=0.014), and those with scar improved from 0±7 vs 5±10 units (P=0.036).