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. 2018 Nov 27;7(23):e010329. doi: 10.1161/JAHA.118.010329

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Unadjusted regression slopes for age across sex and time for IL‐6, hsCRP, MCP‐1, and MMP‐9 among women and men with CAD from MIPS and MIMS2 combined cohorts. Natural log values modeled using repeated‐measures analysis for inflammatory outcome measures of IL‐6, hsCRP, MCP‐1, and MMP‐9 with 95% confidence intervals. Repeated‐measures models were used to investigate age and sex differences across time, testing for interaction of age (continuous) and sex. CAD indicates coronary artery disease; hsCRP, high‐sensitivity C‐reactive protein; IL‐6, interleukin‐6; MCP‐1, monocyte chemoattractant protein‐1; MIMS2, Myocardial Infarction and Mental Stress Study 2; MIPS, Mental Stress Ischemia Prognosis Study; MMP‐9, matrix metallopeptidase 9.