Table 2.

Connectivity parameters for the simulated circuit

Connectivity Parameters	Simulation Parameter Value
Fiber connections to stimulus population	Excitatory fibers
Fibers, n	100
Terminals, n	9
Firing probability at each simulation time step (1.0 ms)	0.05
Synaptic weight	0.002
Synaptic type and time constant (ms)	Excitatory
Time constant (ms)	100
Cell populations	Stim→ChAT	Stim→ChAT+TH	Ach→ChAT+TH	ChAT→SAN	ChAT+TH→SAN
Synaptic type	Excitatory	Excitatory	Inhibitory	Inhibitory	Excitatory
Time constant (ms)	5	5	2	500	5
Min. conduction time (ms)	2	2	2	2	2
Max. conduction time (ms)	2	2	6	6	6
Terminals	WT: 13 AK: 15	WT: 12 AK: 12	WT: 14 AK: 8	WT: 5 AK: 7	3
Synaptic weight	WT: 0.027 Akt: 0.035	WT: 0.0044 Akt: 0.01	WT: 0.001 Akt: 0.000005 Atropine: 0	WT: 0.000005 Akt: 0.000002 Atropine: 0	WT: 0.0005 Akt: 0.0002 PR: 0

Ach indicates acetylcholinesterase; Akt, Akita; ChAT, choline acetyltransferase; PR, propranolol; Stim, stimulation; TH, tyrosine hydroxylase; WT, wild type.