Table 3.
Logistic Regression Analysis of Factors Associated With Adherence to Secondary Prophylaxis
| Observations | Adherent % (n) | Adjusted OR* of Being Adherent Compared With Reference Group (95% CI) Adherent ≥80% Doses | P Value | |
|---|---|---|---|---|
| Sex | ||||
| Male | 2895 | 20 (584) | Ref | ··· |
| Female | 4833 | 25 (1214) | 1.21 (1.02–1.44) | 0.030† |
| Age group | ||||
| Children | 1336 | 30 (394) | Ref | |
| Adolescents | 2008 | 18 (365) | 0.63 (0.52–0.75) | <0.001† |
| Adults | 3444 | 23 (801) | 0.76 (0.62–0.93) | 0.008† |
| Older people | 940 | 25 (238) | 0.75 (0.55–1.01) | 0.054 |
| Residential address | ||||
| Urban | 1151 | 16 (188) | Ref | |
| Not urban | 6577 | 25 (1610) | 1.46 (1.13–1.88) | 0.004† |
| Disease severity | ||||
| Severe RHD | 1805 | 30 (534) | Ref | |
| Moderate RHD | 1391 | 25 (342) | 0.84 (0.69–1.02) | 0.085 |
| Mild RHD | 1804 | 22 (395) | 0.72 (0.59–0.89) | 0.002† |
| ARF only | 2728 | 19 (527) | 0.66 (0.53–0.81) | <0.001† |
| Time since first diagnosis | ||||
| Less than 1 y | 581 | 35 (203) | Ref | |
| At least 1 y | 7147 | 22 (1595) | 0.62 (0.52–0.75) | <0.001† |
| SP regimen | ||||
| 3‐wkly BPG | 66 | 41 (27) | Ref | |
| 4‐wkly BPG | 7662 | 23 (1771) | 0.53 (0.24–1.13) | 0.100 |
| Year | ||||
| 2007 | 1033 | 19 (199) | Ref | |
| 2008 | 1053 | 18 (187) | 0.74 (0.59–0.93) | 0.009† |
| 2009 | 1078 | 21 (225) | 0.91 (0.73–1.14) | 0.411 |
| 2010 | 1096 | 25 (278) | 1.17 (0.94–1.46) | 0.153 |
| 2011 | 1120 | 22 (245) | 0.96 (0.77–1.2) | 0.713 |
| 2012 | 1147 | 25 (285) | 1.16 (0.93–1.44) | 0.185 |
| 2013 | 1201 | 32 (379) | 1.58 (1.27–1.96) | <0.001† |
| Comorbidities | ||||
| Any comorbidity in CCI | ||||
| No | 5585 | 23 (1279) | Ref | |
| Yes | 2143 | 24 (519) | 1.05 (0.86–1.29) | 0.617 |
| Type 2 diabetes mellitus | ||||
| No | 6908 | 23 (1589) | ||
| Yes | 820 | 26 (209) | 1.06 (0.78–1.44) | 0.723 |
| Hypertension | ||||
| No | 6856 | 23 (1572) | Ref | |
| Yes | 872 | 26 (226) | 1.19 (0.87–1.62) | 0.281 |
| Intentional self‐harm | ||||
| No | 7412 | 24 (1742) | Ref | |
| Yes | 316 | 18 (56) | 1.15 (0.69–1.89) | 0.593 |
| Depression | ||||
| No | 7533 | 24 (1770) | Ref | |
| Yes | 195 | 14 (28) | 0.66 (0.34–1.28) | 0.217 |
| Obesity | ||||
| No | 7469 | 23 (1710) | Ref | |
| Yes | 259 | 34 (88) | 1.71 (1.11–2.63) | 0.015† |
| Experience of assault | ||||
| No | 6544 | 25 (1626) | Ref | |
| Yes | 1184 | 15 (172) | 0.62 (0.46–0.85) | 0.002† |
| Hazardous alcohol use | ||||
| No | 6456 | 25 (1602) | Ref | |
| Yes | 1272 | 15 (196) | 0.72 (0.53–0.98) | 0.035† |
| Other drug misuse | ||||
| No | 7392 | 23 (1732) | Ref | |
| Yes | 336 | 20 (66) | 1.21 (0.76–1.91) | 0.427 |
| Total | 7728 | 23 (1798) | ||
BPG indicates benzathine penicillin G; CCI, Charlson Comorbidity Index; OR, odds ratio; RHD, rheumatic heart disease; SP, secondary prophylaxis.
*
Adjusted for all variables listed in table.
†
Statistically significant difference between groups (P<0.05).