Table 3.

Overall Mortality of Subjects^* First Hospitalized for HF, as Determined by Survival of Previously Affected Sibling (Proband)

	Small Model, HR (95% CI)†	P Value	Fully Adjusted Model, HR (95% CI)†	P Value
Proband HF survival <5 y (yes/no)‡	1.98 (1.31–3.00)	0.001	2.02 (1.32–3.09)	0.001
Subject characteristics
Sex (female/male)	0.92 (0.60–1.41)	0.69	0.98 (0.63–1.51)	0.91
Age at onset§	2.14 (1.52–3.02)	<0.001	2.11 (1.44–3.08)	<0.001
Year of onset§			0.97 (0.88–1.06)	0.46
CHD (yes/no)			0.90 (0.58–1.42)	0.66
Diabetes mellitus (yes/no)			2.68 (1.73–4.16)	<0.001
Hypertension (yes/no)			0.80 (0.53–1.20)	0.30
Stroke (yes/no)			2.18 (1.40–3.39)	0.001
VHD (yes/no)			1.75 (1.01–3.00)	0.044

CHD indicates coronary heart disease; CI, confidence interval; HF, heart failure; HR, hazard ratio; VHD, valvular heart disease.

^*Only families with 2 cases of HF and no case of congenital heart disease included.

^†Cox regression HRs, adjustments as specified below.

^‡37 deaths among 90 subjects with proband survival <5 y, from a total of 96 deaths among 373 subjects at risk.

^§Age at onset and year of onset presented as per 10‐ and 1‐y deviations from mean, respectively.