Table 5.

Overall Mortality of Subjects First Hospitalized for HF, as Determined by Survival of Previously Affected Sibling (Proband)—Cardiomyopathies Excluded^*

	Small Model, HR (95% CI)†	P Value	Fully Adjusted Model, HR (95% CI)†	P Value
Proband HF survival <5 y (yes/no)‡	2.04 (1.24–3.36)	0.005	2.22 (1.33–3.71)	0.002
Subject characteristics
Sex (female/male)	1.03 (0.61–1.74)	0.90	1.19 (0.69–2.07)	0.53
Age at onset§	1.68 (1.07–2.64)	0.025	1.65 (1.01–2.70)	0.046
Year of onset§			1.01 (0.90–1.13)	0.88
CHD (yes/no)			0.93 (0.54–1.59)	0.78
Diabetes mellitus (yes/no)			1.96 (1.14–3.36)	0.014
Hypertension (yes/no)			0.86 (0.52–1.42)	0.55
Stroke (yes/no)			2.44 (1.42–4.21)	0.001
VHD (yes/no)			1.34 (0.70–2.60)	0.38

CHD indicates coronary heart disease; CI, confidence interval; HF, heart failure; HR, hazard ratio; VHD, valvular heart disease.

^*Only families with 2 cases of HF and no case of cardiomyopathy or congenital heart disease included.

^†Cox regression HRs, adjustments as specified below.

^‡28 deaths among 66 subjects with proband survival <5 y, from a total of 64 deaths among 241 subjects at risk.

^§Age at onset and year of onset presented as per 10‐ and 1‐y deviations from mean, respectively.