Table 9.

Overall Mortality of Subjects^* First Hospitalized for HF, as Determined by Survival of Previously Affected Sibling (Proband), Stratified by Median Difference in Time Between Subject and Proband Time of Hospitalization

	Small Model, HR (95% CI)†	P Value	Fully Adjusted Model, HR (95% CI)‡	P Value
Occurrence of subject hospitalization within median 1726 d after that of proband
Proband HF survival <5 y (yes/no)§	1.93 (1.16–3.20)	0.012	2.17 (1.25–3.78)	0.006
Occurrence of subject hospitalization median >1726 d after that of proband (total at risk, n=186; deaths, n=33)
Proband HF survival <5 y (yes/no)ǁ	2.07 (1.02–4.22)	0.044	2.98 (1.34–6.62)	0.008

CHD indicates coronary heart disease; CI, confidence interval; HF, heart failure; HR, hazard ratio; VHD, valvular heart disease.

^*Only families with 2 cases of HF and no case of congenital heart disease included.

^†Cox regression HRs, adjusted for subject age at onset and sex, within appropriate strata.

^‡Cox regression HRs, adjusted for subject age at onset, sex, CHD, diabetes mellitus, hypertension, nonrheumatic VHD, and stroke, within appropriate strata.

^§25 deaths among 47 subjects with proband survival <5 y, from a total of 63 deaths among 187 subjects at risk.

^ǁ12 deaths among 43 subjects with proband survival <5 y, from a total of 33 deaths among 186 subjects at risk.