Table 10.

Overall Mortality After First Hospitalization for HF, as Determined by Survival Time of the First Affected Sibling (Proband), Related to CHD in Family and to Mortality of Siblings Without HF^*

	Small Model, HR (95% CI)†	P Value	Fully Adjusted Model, HR (95% CI)‡	P Value
Regular Cox regression calculation
Proband HF survival <5 y (yes/no)§	1.78 (1.09–2.89)	0.021	1.79 (1.08–2.96)	0.024
Cox regression calculation with added adjustment in both models for the relative number of siblings with CHD and for the effect of mortality incidence ratio of non‐HF siblings
Proband HF survival <5 y (yes/no)§	1.80 (1.08–3.02)	0.025	1.91 (1.12–3.25)	0.017

CHD indicates coronary heart disease; CI, confidence interval; HF, heart failure; HR, hazard ratio; VHD, valvular heart disease.

^*Only families with 2 cases of HF and with at least 1 sibling free of HF included. Families with a recorded case of congenital heart disease excluded.

^†Cox regression HRs, adjusted for subject age at onset and sex.

^‡Cox regression HRs, adjusted for subject age at onset, sex, CHD, diabetes mellitus, hypertension, nonrheumatic VHD, and stroke.

^§27 deaths among 70 subjects with proband survival <5 y, from a total of 69 deaths among 276 subjects at risk.