Table 2.
Sensitivity and Subgroup Analyses of All‐Cause Patient Death
| Risk Ratio (95% CI) | |
|---|---|
| All‐cause death at 2 y | |
| Fixed effects model | 1.84 (1.27–2.68) |
| Random effects model | 1.68 (1.15–2.47) |
| All‐cause death at 4 to 5 y | |
| Fixed effects model | 1.94 (1.28–2.96) |
| Random effects model | 1.93 (1.27–2.93) |
| Subgroups (random effects) | |
| Paclitaxel DES only | 1.87 (1.11–3.15) |
| Paclitaxel DCB only | 1.44 (1.04–2.00) |
| Multicenter studies only | 1.48 (1.11–1.97) |
| Dose subgroups (beyond 1 y) | |
| 3.5 μg/mm2 paclitaxel balloon | 2.31 (1.15–4.63) |
| 3.0 μg/mm2 paclitaxel stent | 2.10 (1.15–3.83) |
| 3.0 μg/mm2 paclitaxel balloon | 1.65 (0.95–2.87) |
| 2.0 μg/mm2 paclitaxel balloon | 1.27 (0.70–2.32) |
| Trial sequential analysis (TSA; random effects at 2 y) | |
| TSA diversity adjusted (α=5%, β=20%) | 1.70 (1.19–2.43) |
| TSA diversity adjusted (α=5%, β=10%) | 1.70 (1.24–2.33) |
| TSA diversity adjusted (α=1%, β=10%) | 1.70 (1.08–2.69) |
CI indicates confidence interval; DCB, drug‐coated balloon; DES, drug‐eluting stent.