Table 2.

Cardiac Predictors of Brain Structures (N=1829)

	WMH β Coefficientsa	95% CI	P Values
LV structure
End‐diastolic left ventricular diameter, cm	1.47	−0.31 to 3.24	0.11
Mean LV wall thickness, mm	0.66	0.08‐1.25	0.03
LV mass index (10 g/m2)	0.64	0.19‐1.08	<0.01
LV systolic function
Ejection fraction (per 5%)	−0.25	−0.80 to 0.30	0.38
Average peak longitudinal strain, %	0.31	−0.04 to 0.65	0.08
LV diastolic function
Lateral early diastolic myocardial velocity, cm/s	−0.08	−0.39 to 0.23	0.61
E‐Em lateral ratio, cm/s	0.15	−0.07 to 0.36	0.18
LA volume index (5 mL/m2)	0.18	−0.25 to 0.61	0.42

	Presence of Infarct Odds Ratiosa	95% CI	P Values
End‐diastolic left ventricular diameter, cm	1.21	0.88‐1.68	0.24
Mean LV wall thickness, mm	1.11	1.01‐1.23	0.04
LV mass index, 10 g/m2	1.08	1.00‐1.17	0.04
LV systolic function
Ejection fraction, per 5%	0.85	0.77‐0.95	<0.01
Average peak longitudinal strain, %	1.04	0.98‐1.10	0.24
LV diastolic function
Lateral early diastolic myocardial velocity, cm/s	0.94	0.87‐1.01	0.08
E‐Em lateral ratio, cm/s	1.00	0.97‐1.04	0.82
LA volume index, 5 mL/m2	1.06	0.97‐1.16	0.19

BMI indicates body mass index; CI, confidence interval; E‐Em lateral ratio, early diastolic transmitral flow velocity to early diastolic lateral mitral annular tissue velocity; LA, left atrial; LDL, low‐density lipoprotein; LV, left ventricular.

^aAdjusted for age, sex, estimated total intracranial volume, education, hypertension, diabetes mellitus, smoking, alcohol, BMI, LDL, and history of myocardial infarction. Participants with heart failure or atrial fibrillation were excluded.