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. 2019 Mar 1;12:52. doi: 10.3389/fnmol.2019.00052

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Copyright © 2019 Delloye-Bourgeois and Castellani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microenvironment-driven guidance of trunk neural crest cells (NCCs) along defined migration pathways. Left: schematic view of neural crest (NC) subtypes along the rostro-caudal embryonic axis. Relevant somites to delimit NC populations are numbered on the scheme. Right: transverse section schematic view of trunk NCCs successive waves of migration, figured with blue arrows. Receptors involved in NCCs guidance interaction with environmental cues are listed for each pathway. Examples of environmental cues produced by key structural choice points are mentioned (in red, repulsive cues; in green, attractive cues). From the dermamyotome: Slit2, Draxin and Sema3A; from the posterior sclerotome: CXCL12, Sema3F and EphrinB1/2; from the Notochord and forelimb: Sema3A; from the intersomitic vessels: artemin; from the para-aortic mesenchyme: CXCL12 and neuregulin1 (NRG1). AM, adrenal medulla; DA, dorsal aorta; dm, dermamyotome; DRG, dorsal root ganglia; isv, intersomitic vessel; Me, mesonephros; NT, neural tube; Me, mesonephros; No, notochord; pSG, primary sympathetic ganglia; scl, sclerotome; SG, sympathetic ganglion.