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. 2019 Feb 15;8(4):e010926. doi: 10.1161/JAHA.118.010926

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Early deteriorating cardiac function, and development of left ventricular hypertrophy (LVH) in SHR in vivo. A, Ejection fractions (EF) and B, left ventricular mass to body weight ratios (LVM/BW), were determined in SHR (n=8) and WKY (n=5) at 1, 2, 3, and 5 months of age using CMR. C, Heart weight to body weight ratios ex vivo. Entire heart weights were determined after dissection from SHR (n=6) and WKY (n=6) and normalized to body weight (HW/BW). All data are shown as mean±SE. BW indicates body weight; CMR, cardiac magnetic resonance; EF, ejection fraction; HW, heart weight; LVH, left ventricular hypertrophy; LVM, left ventricular mass; SHR, spontaneously hypertensive rats; WKY, Wistar Kyoto rats. *P<0.05 and ^† P<0.001 SHR vs WKY.