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. 2019 Feb 15;8(4):e010926. doi: 10.1161/JAHA.118.010926

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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mTOR and ER stress activation in SHR. A, SHR (n=6) and WKY (n=6) hearts were immunoblotted for phospho‐p70S6K (p‐p70S6K), a marker for mTOR activity, total p70S6K, and GAPDH at 1, 2, 3, and 5 months of age. B, Signal intensities for p‐p70S6K and p70S6K were normalized to GAPDH, and p‐p70S6K/p70S6K ratios determined. Results were normalized within age groups (for which samples were analyzed on the same immunoblots) and fold changes reported. C, SHR (n=6) and WKY (n=6) hearts were immunoblotted for GRP78, a marker for endoplasmic reticulum stress, and GAPDH. D, Signal intensities for GRP78 normalized to GAPDH are presented. Results were normalized within age groups (for which samples were analyzed on the same immunoblots) and fold changes reported. All data are shown as mean±SE. *P<0.05 and ^† P<0.001 SHR vs WKY. SHR indicates spontaneously hypertensive rats; WKY, Wistar Kyoto rats.