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. 2019 Feb 15;8(4):e010926. doi: 10.1161/JAHA.118.010926

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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A, Changes in cardiac fatty acid, BCAA, and glucose metabolites and markers of oxidative stress and inflammation in SHR. Metabolites were analyzed in hearts of SHR (n=9) and WKY (n=10) at 2 months of age as described in S1. Data for biochemicals in raw area counts were rescaled to set medians equal to 1 and plotted. Data are shown as mean±SE. P<0.05 for all metabolites comparing SHR with WKY. B, Circulating BCAA, glucose, FFA, and insulin levels in SHR. Total circulating metabolite levels were measured in SHR (n=8) and WKY (n=8) at 2 months of age. BCAA were significantly higher in SHR (*P<0.05). There were no significant differences in circulating glucose, FFA and insulin concentrations between SHR and WKY. BCAA indicates branched chain amino acids; FFA; free fatty acids; SHR, spontaneously hypertensive rats; WKY, Wistar Kyoto rats. *P<0.05.