Table 1.
Location | Top Canonical Pathways and Diseases and Functions | Involved Genes | P Value |
---|---|---|---|
Septum* | LXR/RXR activation | LY96, SERPINF1, CLU, ABCA1, APOD | 4.47E‐04 |
Clathrin‐mediated endocytosis signaling | OR1A1, ACTA2, FGF7, CLU, APOD | 2.95E‐03 | |
ILK signaling | SNAI2, ACTA2, PPP2R3A, MYL1 | 1.70E‐02 | |
Atherosclerosis signaling | VCAM1, CLU, APOD | 2.75E‐02 | |
Lipid metabolism, metabolic disease, and adipose tissue | ABCA1, ARNTL, CES1, CLU, EPHX2, GNMT, INSR, POMC, VCAM1, MSTN, PLIN2, PRLR, RDH16, APOD, FGF7, PTGFR, XDH, SLCO1A2, ACTA2, CCK, HK2, IL15, KCNA5, MME, P2RY1, ROBO2, SERPINF1, TGFBI, TSPO, ZBTB12, ZNRD1 | 2.53E‐06 to 1.00E‐04 | |
Cell death and survival (apoptosis) | ABCA1, ALDOC, APOD,CCK, CES1, CLU, CXCL2, DOCK8, EPHX1, EPHX2, EYA4, FAP, FBXO32, FGF7, FOXF2, FRZB, GNMT, HK2, IFNA1/IFNA13, IL15, INSR, KCNA5, KLF8, LUM, MME, MSTN, NDEL1, NTRK3, OR10A3, PLK2, POMC, PPP2R3A, PRLR, PTGFR, RASGRP2, RPS6KL1, SERPINF1, SLC22A3, SNAI2, STC1, TDP2, TSPO, VCAM1, XDH | 9.54E‐05 to 1.22E‐03 | |
Cellular movement | ACTA2, CCK, CCL21, CLU, CXCL2, DOCK8, FAP, FGF7, IL15, INSR, KLF8, LUM, LY96, MME, NDEL1, NTRK3, P2RY1, PHACTR1, POMC, RASGRP2, ROBO2, SERPINF1, SNAI2, STC1, TDP2, TGFBI, TSPO, VCAM1 | 1.63E‐04 to 2.25E‐04 | |
Cardiovascular disease (atherosclerosis) | ABCA1, ALDH5A1, CES1, CLU, CXCL2, EPHX2, P2RY1, PLIN2, VCAM1, XDH | 7.40E‐04 | |
Free wall† | LXR/RXR Activation | LY96, MSR1, SERPINF1, CLU, APOD | 1.82E‐04 |
Clathrin‐mediated endocytosis signaling | OR1A1, TFRC, FGF7, CLU, APOD | 1.26E‐03 | |
Calcium signaling | RCAN1,TRDN, MYL1 | ||
Cardiac hypertrophy | ARNTL, CSRP3, EPOR, LUM, MSTN, RCAN1, EPOR, mir‐30, RCAN1, NOX4, CLU, EPHX2, LOX, NTRK3, SDC4, TFRC, UTF1,TRDN | 2.05E02 to 4.20E‐05 | |
Cell‐to‐cell signaling and interaction | F5, GYLTL1B, HRH4, LOX, LY96, MSR1, SDC4, SERPINF1, TFRC | 5.96E‐04 to 4.34E‐03 | |
Metabolic disease | APOD, CLU, MSR1, PTGFR, ROBO2, SERPINF1, XDH, ARNTL, CCDC12, CTH, CYP4A11, EPOR, mir‐30, MS4A6A, MSR1, NOX4, TRIM31, ZNRD1 | 4.45E‐05 to 7.01E‐03 |
ILK indicates integrin‐linked kinase; LXR/RXR, liver X receptor/retinoid X receptor.
The canonical pathways/diseases/functions in the network derived from 301 differentially expressed genes of left ventricular septum.
The canonical pathways/diseases/functions in the network derived from 293 differentially expressed genes of left ventricular free wall.