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. 2019 Jan 5;8(1):e009146. doi: 10.1161/JAHA.118.009146

Table 1.

Top Involved Canonical Pathways and Top Diseases and Functions in the Network Between Pacing and Sham Control Groups Using Ingenuity Pathway Analysis Global Molecular Network Algorithm

Location Top Canonical Pathways and Diseases and Functions Involved Genes P Value
Septum* LXR/RXR activation LY96, SERPINF1, CLU, ABCA1, APOD 4.47E‐04
Clathrin‐mediated endocytosis signaling OR1A1, ACTA2, FGF7, CLU, APOD 2.95E‐03
ILK signaling SNAI2, ACTA2, PPP2R3A, MYL1 1.70E‐02
Atherosclerosis signaling VCAM1, CLU, APOD 2.75E‐02
Lipid metabolism, metabolic disease, and adipose tissue ABCA1, ARNTL, CES1, CLU, EPHX2, GNMT, INSR, POMC, VCAM1, MSTN, PLIN2, PRLR, RDH16, APOD, FGF7, PTGFR, XDH, SLCO1A2, ACTA2, CCK, HK2, IL15, KCNA5, MME, P2RY1, ROBO2, SERPINF1, TGFBI, TSPO, ZBTB12, ZNRD1 2.53E‐06 to 1.00E‐04
Cell death and survival (apoptosis) ABCA1, ALDOC, APOD,CCK, CES1, CLU, CXCL2, DOCK8, EPHX1, EPHX2, EYA4, FAP, FBXO32, FGF7, FOXF2, FRZB, GNMT, HK2, IFNA1/IFNA13, IL15, INSR, KCNA5, KLF8, LUM, MME, MSTN, NDEL1, NTRK3, OR10A3, PLK2, POMC, PPP2R3A, PRLR, PTGFR, RASGRP2, RPS6KL1, SERPINF1, SLC22A3, SNAI2, STC1, TDP2, TSPO, VCAM1, XDH 9.54E‐05 to 1.22E‐03
Cellular movement ACTA2, CCK, CCL21, CLU, CXCL2, DOCK8, FAP, FGF7, IL15, INSR, KLF8, LUM, LY96, MME, NDEL1, NTRK3, P2RY1, PHACTR1, POMC, RASGRP2, ROBO2, SERPINF1, SNAI2, STC1, TDP2, TGFBI, TSPO, VCAM1 1.63E‐04 to 2.25E‐04
Cardiovascular disease (atherosclerosis) ABCA1, ALDH5A1, CES1, CLU, CXCL2, EPHX2, P2RY1, PLIN2, VCAM1, XDH 7.40E‐04
Free wall LXR/RXR Activation LY96, MSR1, SERPINF1, CLU, APOD 1.82E‐04
Clathrin‐mediated endocytosis signaling OR1A1, TFRC, FGF7, CLU, APOD 1.26E‐03
Calcium signaling RCAN1,TRDN, MYL1
Cardiac hypertrophy ARNTL, CSRP3, EPOR, LUM, MSTN, RCAN1, EPOR, mir‐30, RCAN1, NOX4, CLU, EPHX2, LOX, NTRK3, SDC4, TFRC, UTF1,TRDN 2.05E02 to 4.20E‐05
Cell‐to‐cell signaling and interaction F5, GYLTL1B, HRH4, LOX, LY96, MSR1, SDC4, SERPINF1, TFRC 5.96E‐04 to 4.34E‐03
Metabolic disease APOD, CLU, MSR1, PTGFR, ROBO2, SERPINF1, XDH, ARNTL, CCDC12, CTH, CYP4A11, EPOR, mir‐30, MS4A6A, MSR1, NOX4, TRIM31, ZNRD1 4.45E‐05 to 7.01E‐03

ILK indicates integrin‐linked kinase; LXR/RXR, liver X receptor/retinoid X receptor.

*

The canonical pathways/diseases/functions in the network derived from 301 differentially expressed genes of left ventricular septum.

The canonical pathways/diseases/functions in the network derived from 293 differentially expressed genes of left ventricular free wall.