Table 5.

Area Under the Curve, NRI, and IDI

	c‐Statistic	P Value*	Category Free NRI (95% CI)	Correctly Reclassified Higher (%)	Correctly Reclassified Lower (%)	IDI	P Value*
Model 1 (n=1131)
CHD events (n=256)
Conventional risk factors	0.625
+ln‐NGAL	0.637	0.175	0.258	14.9	11.0	0.013	<0.001
+Quartiles of NGAL	0.641	0.135	0.329	23.2	9.8	0.017	<0.001
+Above the median NGAL	0.639	0.146	0.371	30.6	6.5	0.015	<0.001
Model 2 (n=807)
CHD events (n=170)
Conventional risk factors	0.637
+ln‐NGAL	0.660	0.064	0.366	18.3	18.3	0.029	<0.001
+Quartiles of NGAL	0.662	0.078	0.451	31.7	13.4	0.029	<0.001
+Above the median NGAL	0.658	0.149	0.471	36.6	10.5	0.027	<0.001

BMI indicates body mass index; CHD, coronary heart disease; IDI, integrated discrimination improvement; NGAL, neutrophil gelatinase‐associated lipocalin; NRI, net reclassification improvement.

^*Compared with conventional risk factors (Model 1 including age, BMI, current smoking, systolic blood pressure, prescription of antihypertensive medications, diabetes mellitus, and treatment code [calcium or placebo] or Model 2 including age, total cholesterol, high‐density lipoprotein cholesterol, current smoking, systolic blood pressure, prescription of antihypertensive medications, diabetes mellitus, and treatment code [calcium or placebo]).