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. 2019 Mar 7;9:3909. doi: 10.1038/s41598-019-40602-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Animal model of regression. In the regular model, animals were either put on regular WTD as a control or WTD supplemented with rivaroxaban for 14 weeks. In our reversed model, all animals received WTD during the first 14 weeks. After 14 weeks, the group was divided in 2:1 group continued with WTD for the remainder of 6 weeks, and one group was switched to WTD supplemented with rivaroxaban.