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. 2019 Mar 7;9:3909. doi: 10.1038/s41598-019-40602-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plaque development in the aortic arch of ApoE^−/− mice. The aortic arch of rivaroxaban treated mice showed less plaque formation than control (−46%). This was associated with a more stable phenotype of the plaque as measured by a thicker fibrotic cap (29.50 μm (26.00–40.50)) compared to control (41.00 μm (33.25–54.75)), reduced macrophages (17.68% (13.25–19.46) vs 9.90% (9.23–11.24), and decreased necrotic core (34.56% (27.85–40.63) vs 22.92% (14.94–28.43). *p < 0.05, **p < 0.01, ***p < 0.001. All data were in median (IQR) n = 10 for each group.