Table 4.
Target genes and associated pathways for differentially expressed genes in lung tissue of female exposed to ozone mice in the follicular phase
| A. Molecules associated with differentially expressed genes | |||||
| C8 | IFN‐I | CCL11 | TLR | IFNB | IFNγ |
| CCL20 | IL12 | CCL7 | CCL17 | MMP | IL12 |
| Ciap | LTB | CXCL3 | CD14 | TNF | JAK |
| CXCL2 | SAA | IFNAR | CR3 | CCL2 | NFκB |
| ERK1/2 | CCL11 | IL17R | CXCL6 | CXCL10 | |
| B. Differences in top diseases and bio‐functions | |||||
| Diseases and disorders | P Value | ||||
| Connective tissue disorders | 1.78E‐04–1.84E‐16 | ||||
| Immunological disease | 2.48E‐04–1.84E‐16 | ||||
| Inflammatory disease | 1.78E‐04–1.84E‐16 | ||||
| C. Top molecular and cellular functions | |||||
| Molecular and cellular functions | P Value | ||||
| Cell‐to‐cell signaling and interaction | 2.91E‐04–1.08E‐18 | ||||
| Cellular movement | 2.97E‐04–1.08E‐18 | ||||
| Cellular development | 2.61E‐04–6.48E‐12 | ||||
| D. Top physiological system development and function | |||||
| Development and function | P Value | ||||
| Immune cell trafficking | 2.62E‐04–6.08E‐18 | ||||
| Hematological system development and function | 2.89E‐04–5.41E‐17 | ||||
| Tissue development | 2.61E‐04–2.61E‐15 | ||||
| E. Top associated network functions | |||||
| Associated network functions | Score | ||||
| Cell‐to‐cell signaling and interaction, cellular movement, immune cell trafficking | 31 | ||||