Table 5.
Target genes and associated pathways for differentially expressed genes in lung tissue of female exposed to ozone mice in the luteal phase
| A. Molecules associated with differentially expressed genes | |||||
| IFNA7 | CCL17 | TLR10 | PTGS2 | IL12 | TLR13 |
| IL18R | IFNW1 | TLR6 | TLR11 | NXNL1 | PIK3AP1 |
| NFATC | IL18RAP | IL10R | TNF | SARM1 | MYD88 |
| PI3K | NFKB | ILIRL2 | ATF | TLR12 | IFNA10 |
| B. Differences in top diseases and bio‐functions | |||||
| Diseases and disorders | P Value | ||||
| Cancer | 1.96E‐03–1.20E‐06 | ||||
| Gastrointestinal disease | 1.96E‐03–1.20E‐06 | ||||
| Hereditary disorder | 5.62E‐04–1.20E‐06 | ||||
| C. Top molecular and cellular functions | |||||
| Molecular and cellular functions | P value | ||||
| Cellular function and maintenance | 1.68E‐03–1.31E‐08 | ||||
| Cellular growth and proliferation | 1.82E‐03–7.89E‐08 | ||||
| Cellular movement | 1.40E‐03–2.58E‐06 | ||||
| D. Top physiological system development and function | |||||
| Development and function | P value | ||||
| Tissue development | 1.96E‐03–1.31E‐08 | ||||
| Tissue morphology | 1.68E‐03–1.31E‐08 | ||||
| Cell‐mediated immune response | 1.66E‐03–2.58E‐06 | ||||
| E. Top associated network functions | |||||
| Associated network functions | Score | ||||
| Inflammatory response, infectious diseases, organismal injury, and abnormalities | 9 | ||||