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. 2019 Mar 7;9:3893. doi: 10.1038/s41598-019-40601-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Knee joint integrity. White thick arrows indicate healthy bone marrow. Black thick arrows indicate that the normal marrow has been replaced with a fibrotic marrow. Black thin arrows indicate that the fibrous and granulation tissue extended to the subchondral bone and to the tidemark. ^♦Indicates difference from chow group, while *Indicates difference from HFS group. Chow: chow control diet; HFS: high fat/high sucrose diet; F: prebiotic fibre; E: aerobic exercise. Values are means ± 1 SEM (white line, bar = 200 µm).