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. 2019 Mar 7;9:3788. doi: 10.1038/s41598-019-39789-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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2-Deoxy-D-glucose significantly decreases the migration, invasion and resistance to anoikis of Hs578Ts(i)₈ compared to Hs578T cells. (a,b) Wound-healing assays indicate that 2-DG significantly decreases the rate of migration of the Hs578T(i)₈ and Hs578T cell variants, with effects on the Hs578T(i)₈ population being most substantial. (c,d) Invasion assays indicate 2-DG significantly decreases the rate of invasion of Hs578T(i)₈, but not Hs578T, cells; (e,f) anoikis assays showed 2-DG to significantly decreases the apoptosis resistance of the Hs578T(i)₈ variant, but not the Hs578T cells. Data is expressed as the mean ± SEM of n = 3 experiments, where *p < 0.05, **p < 0.01, ***p < 0.001.