Table 4.
Selected Bivariate Associations for Labs and Medications Received
| ES-GNR | ER-GNR | P | ACS-GNR | ACR-GNR | P | |
|---|---|---|---|---|---|---|
| No. | 16861 | 563 | 29664 | 1307 | ||
| Labs on day of culture | ||||||
| WBC | 12.4 [8.6 to 17.1] | 13.5 [9.4 to 19.3] | <.001 | 12.4 [8.6 to 17.2] | 14.15 [9.7 to 19.45] | <.001 |
| Hemoglobin | 10.1 [8.7 to 11.7] | 9.1 [8.2 to 10.3] | <.001 | 9.9 [8.7 to 11.5] | 9.2 [8.2 to 10.4] | <.001 |
| Hematocrit | 30.8 [26.7 to 35.4] | 28.1 [25 to 31.8] | <.001 | 30.5 [26.6 to 35] | 28.6 [25.3 to 32.3] | <.001 |
| Platelets | 204 [132 to 287] | 207 [103 to 306] | .767 | 205 [132 to 290] | 227 [132 to 329] | <.001 |
| Sodium | 137.3 (5.7) | 137.7 (5.3) | .158 | 137.3 (5.5) | 138.1 (5.6) | <.001 |
| Potassium | 4.1 (0.6) | 4.1 (0.6) | .394 | 4.1 (0.6) | 4.1 (0.6) | .019 |
| Chloride | 102.4 (6.6) | 102.2 (6.4) | .488 | 102.6 (6.5) | 102.5 (7) | .730 |
| Bicarbonate | 24.2 (4.5) | 24.4 (4.9) | .215 | 24.3 (4.7) | 25.3 (5.4) | <.001 |
| Anion gap | 10.7 (4) | 11 (4.3) | .086 | 10.4 (4) | 10.3 (4.3) | .310 |
| Creatinine | 1.4 (1.3) | 1.5 (1.4) | .011 | 1.4 (1.4) | 1.4 (1.3) | .895 |
| BUN | 28 (22.5) | 33.9 (25.1) | <.001 | 28.3 (23.1) | 34.7 (29) | <.001 |
| GFR | 69 [39 to 100] | 63 [33 to 100] | .035 | 71 [39 to 100] | 73 [38 to 100] | .192 |
| Glucose | 137 (60) | 135 (56) | .470 | 135 (58) | 134 (58) | .416 |
| Magnesium | 1.7 (0.3) | 1.7 (0.3) | <.001 | 1.7 (0.3) | 1.7 (0.3) | <.001 |
| Calcium | 8.6 (0.8) | 8.6 (0.9) | .985 | 8.6 (0.8) | 8.6 (0.9) | .673 |
| Phosphorus | 3.3 (1.2) | 3.4 (1.4) | .080 | 3.3 (1.1) | 3.4 (1.3) | .026 |
| Days since: | ||||||
| Last antibiotic | 0 [0 to 12] | 0 [0 to 2] | <.001 | 0 [0 to 8] | 0 [0 to 0] | <.001 |
| Last aminoglycoside | 100 [100 to 100] | 100 [100 to 100] | <.001 | 100 [100 to 100] | 100 [100 to 100] | <.001 |
| Last antipseudomonal carbapenema | 100 [100 to 100] | 100 [29 to 100] | <.001 | 100 [100 to 100] | 100 [6 to 100] | <.001 |
| Last ertapenem | 100 [100 to 100] | 100 [100 to 100] | <.001 | 100 [100 to 100] | 100 [100 to 100] | <.001 |
| Last carbapenem (any) | 100 [100 to 100] | 100 [10 to 100] | <.001 | 100 [100 to 100] | 100 [0 to 100] | <.001 |
| Last fluoroquinolone | 100 [100 to 100] | 100 [44 to 100] | <.001 | 100 [100 to 100] | 100 [42 to 100] | <.001 |
| Last penicillin | 100 [2 to 100] | 27 [1 to 100] | <.001 | 100 [1 to 100] | 67.5 [3.5 to 100] | .005 |
| Last anti-MRSA | 100 [1 to 100] | 7 [0 to 100] | <.001 | 100 [0 to 100] | 5 [0 to 100] | <.001 |
| Last colistin | 100 [100 to 100] | 100 [100 to 100] | <.001 | 100 [100 to 100] | 100 [100 to 100] | <.001 |
| Last aztreonam | 100 [100 to 100] | 100 [100 to 100] | .005 | 100 [100 to 100] | 100 [100 to 100] | <.001 |
| Last beta-lactam | 1 [0 to 100] | 0 [0 to 10] | <.001 | 0 [0 to 100] | 0 [0 to 11] | <.001 |
| Last acid suppressant | 0 [0 to 100] | 0 [0 to 0] | <.001 | 0 [0 to 100] | 0 [0 to 1] | <.001 |
| Last probiotic | 100 [100 to 100] | 100 [100 to 100] | <.001 | 100 [100 to 100] | 100 [100 to 100] | <.001 |
| Last steroid | 100 [100 to 100] | 100 [2 to 100] | <.001 | 100 [58 to 100] | 100 [68.5 to 100] | .925 |
| Last chemotherapy | 100 [100 to 100] | 100 [100 to 100] | .197 | 100 [100 to 100] | 100 [100 to 100] | .079 |
| Last immunosuppressant | 100 [10 to 100] | 100 [0 to 100] | <.001 | 100 [1 to 100] | 100 [26.5 to 100] | .218 |
| Last blood product | 100 [100 to 100] | 100 [9 to 100] | <.001 | 100 [100 to 100] | 100 [35 to 100] | <.001 |
Normally distributed outcomes are reported as mean (SD), and non–normally distributed outcomes are reported as median [interquartile range]. Binary outcomes are reported as percent positive.
Abbreviations: ACR-GNR, antipseudomonal (nonertapenem) carbapenem-resistant Gram-negative rods; ACS-GNR, antipseudomonal carbapenem-susceptible Gram-negative rods; BUN, blood urea nitrogen; ER-GNR, ertapenem-resistant Gram-negative rods; ES-GNR, ertapenem-susceptible Gram-negative rods; GFR, race-adjusted glomerular filtration rate; MRSA, methicillin-resistant Staphylococcus aureus; WBC, white blood cell count.
aAntipseudomonal carbapenem: meropenem, imipenem, or doripenem.