Figure 12.

Discrete state Model 4. Left: State transition diagram of a single compartment. The initial state for all compartments is ‘unattached’. The cell has failed if one compartment is in state ‘exit’ while another one is in state ‘unattached’ at the same time. Presented below is the same model with references to species from Model 3. Right: Simulation of the discrete 4 state model using Python. Here, we show the probability of checkpoint success, that is, while one kinetochore is still ‘unattached’ no other one is in the ‘exit’ state. The x-axis (0–1) shows the probability p of a transition from ‘attached’ to ‘about to exit’ while the y-axis (0–10) shows the distance radius of a neighborhood relation. The graphic shows that the rate of success is independent of the probability p and only depends on the range of a neighborhood. Namely, the more neighbors are considered before moving on to ‘exit’ state the more likely the mitosis is successful.