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. 2019 Mar 7;9:3902. doi: 10.1038/s41598-019-40648-w

Table 7.

Deviation of the four-state model (Model 4) via six states. Two states can be eliminated, because they are unlikely due to a quick production of the Inhibitor.

Outputsignal KinU KinA Activator Inhibitor State
‘Wait’ x x ‘unattached’
‘Wait’ x x x Unlikely, because Activator is quickly converted to Inhibitor
‘Go’ x x Unlikely, because Activator is quickly converted to Inhibitor
‘Wait’ x x ‘attached’
‘Wait’ x x x ‘about to exit’
‘Go’ x x ‘exit’