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A brief one - carbon metabolic cycle. Exogenous folate was reduced twice to form THF to provide a carrier for a carbon unit, SHMT1/2 converted serine to glycine and provided one-carbon units. In the mitochondria, MTHFD2 catalyses the conversion of 5,10-meTHF to 10-formyl-THF, which were the substrates for the synthesis of purines and pyrimidines in cells.
