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Suppression of MTHFD2 induces changes in intracellular one-carbon metabolism. Red labels indicate the depletion of enzyme expression including SHMT2 and MTHFD1L, 5,10-meTHF accumulates in mitochondria because it cannot pass through mitochondrial membrane, the intracellular synthesis of purine decreases due to the depletion of 10-formyl-THF.
