Figure 4.

DANCR promotes growth and metastasis of NSCLC cells in vivo. A and B. Effects of DANCR knockdown on tumor growth in vivo. Control and DANCR knockdown A549 cells were injected subcutaneously into nude mice. A. The tumor growth curves. B. Tumor weights. C and D. Effects of DANCR overexpression on tumor growth in vivo. Control and DANCR overexpressing H1299 cells were injected subcutaneously into nude mice. C. The tumor growth curves. D. Tumor weights. E and F. Control and DANCR knockdown A549 cells were injected into the lateral tail vein of the nude mice. After 8 weeks, the lung metastasis was detected. E. Incidence of lung metastasis in each group of nude mice. F. The numbers of hepatic and lung metastases per mouse were calculated. G and H. Control and DANCR overexpressing H1299 cells were injected into the lateral tail vein of the nude mice. After 8 weeks, the lung metastasis was detected. G. Incidence of lung metastasis in each group of nude mice. H. The numbers of hepatic and lung metastases per mouse were calculated. Date are presented as the means ± SD. *P<0.05.