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. 2019 Mar 7;9:3839. doi: 10.1038/s41598-019-40495-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression modulated by VP. (A) Expression heat map of sample-to-sample distances on the matrix of variance-stabilized data for overall gene expression. trt = treatment; C = Control; VP = Verteporfin treated. Clustering differentiates between control and VP treated samples. This heatmap was built using DESeq 2 on normalized gene read counts. All of the rlog values of the dispersion estimates were clustered using the R distance function (dist) to calculate the Euclidean distance between samples. Distance plot for HEC-1A and HEC-1B cell lines showing their control and VP-treated versions. (B) Differential gene expression, with fold difference between log₂ normalized expression in control (n = 2) and VP treated (n = 2) plotted versus −log₁₀ adjusted P-value. Each gene is colored based on the log₁₀ base mean expression.