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. 2019 Mar 7;9:3839. doi: 10.1038/s41598-019-40495-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) NCr nude mice showing tumor regression after VP treatments in a subcutaneous model after 21 days. n = 10/group. (B) Tumor volume growth curve and (C) Body weight curves in control and VP treated mice. (D) Quantitation of VP in mice plasma samples by LC-MS/MS analysis. (E) Western blot showing VP-induced inhibition of cell cycle proteins in subcutaneous tumors of mice. Error bars indicate Mean ± SEM.