Table 3.
Gene Ontology for top 20 upregulated genes in HEC-1A and HEC-1B after VP treatment (GO term results with FDR-adjusted p < 0.05), sorted by fold enrichment. The p-value was adjusted for False Discovery Rate (FDR).
| GO biological process complete | H. sapiens - REFLIST (21042) | upregulated (20) | upregulated (expected) | upregulated (Fold enrichment) | upregulated (over/under) | upregulated (raw P-value) | upregulated (FDR) |
|---|---|---|---|---|---|---|---|
| Positive regulation of transforming growth factor beta1 production | 6 | 2 | 0.01 | >100 | + | 2.39E-05 | 9.35E-03 |
| Positive regulation of transforming growth factor beta production | 17 | 2 | 0.02 | >100 | + | 1.45E-04 | 3.07E-02 |
| Regulation of multicellular organismal process | 2827 | 12 | 2.69 | 4.47 | + | 1.55E-06 | 2.01E-03 |
| Positive regulation of multicellular organismal process | 1568 | 9 | 1.49 | 6.04 | + | 5.69E-06 | 3.87E-03 |
| Regulation of transforming growth factor beta1 production | 10 | 2 | 0.01 | >100 | + | 5.62E-05 | 1.63E-02 |
| Positive regulation of osteoblast proliferation | 11 | 2 | 0.01 | >100 | + | 6.64E-05 | 1.85E-02 |
| Regulation of osteoblast proliferation | 23 | 2 | 0.02 | 91.49 | + | 2.54E-04 | 4.56E-02 |
| Regulation of lipoprotein metabolic process | 13 | 2 | 0.01 | >100 | + | 8.93E-05 | 2.37E-02 |
| Regulation of protein metabolic process | 2809 | 10 | 2.67 | 3.75 | + | 9.29E-05 | 2.38E-02 |
| Cell adhesion mediated by integrin | 24 | 3 | 0.02 | >100 | + | 2.11E-06 | 2.36E-03 |
| Cell adhesion | 889 | 9 | 0.84 | 10.65 | + | 4.92E-08 | 2.56E-04 |
| Biological adhesion | 895 | 9 | 0.85 | 10.58 | + | 5.21E-08 | 2.04E-04 |
| Positive regulation of macrophage activation | 23 | 2 | 0.02 | 91.49 | + | 2.54E-04 | 4.51E-02 |
| Endodermal cell differentiation | 41 | 3 | 0.04 | 76.98 | + | 9.46E-06 | 5.10E-03 |
| Cell differentiation | 3636 | 12 | 3.46 | 3.47 | + | 2.27E-05 | 9.09E-03 |
| Cellular developmental process | 3728 | 12 | 3.54 | 3.39 | + | 2.94E-05 | 1.05E-02 |
| Developmental process | 5654 | 16 | 5.37 | 2.98 | + | 1.13E-06 | 1.61E-03 |
| Endoderm formation | 51 | 3 | 0.05 | 61.89 | + | 1.76E-05 | 7.25E-03 |
| Endoderm development | 76 | 3 | 0.07 | 41.53 | + | 5.53E-05 | 1.63E-02 |
| Tissue development | 1704 | 11 | 1.62 | 6.79 | + | 8.51E-08 | 2.22E-04 |
| Anatomical structure development | 5299 | 16 | 5.04 | 3.18 | + | 4.38E-07 | 8.55E-04 |
| Formation of primary germ layer | 116 | 4 | 0.11 | 36.28 | + | 4.52E-06 | 3.72E-03 |
| Anatomical structure formation involved in morphogenesis | 870 | 8 | 0.83 | 9.67 | + | 7.12E-07 | 1.11E-03 |
| Anatomical structure morphogenesis | 2104 | 12 | 2.00 | 6.00 | + | 5.98E-08 | 1.87E-04 |
| Gastrulation | 161 | 4 | 0.15 | 26.14 | + | 1.60E-05 | 7.13E-03 |
| Embryonic morphogenesis | 563 | 5 | 0.54 | 9.34 | + | 1.55E-04 | 3.11E-02 |
| Embryo development | 919 | 7 | 0.87 | 8.01 | + | 1.45E-05 | 6.89E-03 |
| Multicellular organism development | 4918 | 15 | 4.67 | 3.21 | + | 1.56E-06 | 1.87E-03 |
| Multicellular organismal process | 6807 | 16 | 6.47 | 2.47 | + | 1.66E-05 | 7.19E-03 |
| Integrin-mediated signaling pathway | 92 | 3 | 0.09 | 34.31 | + | 9.59E-05 | 2.34E-02 |
| Cellular response to stimulus | 6741 | 15 | 6.41 | 2.34 | + | 1.02E-04 | 2.41E-02 |
| Extracellular matrix organization | 323 | 8 | 0.31 | 26.06 | + | 3.66E-10 | 5.72E-06 |
| Extracellular structure organization | 366 | 8 | 0.35 | 23.00 | + | 9.59E-10 | 7.50E-06 |
| Cell-matrix adhesion | 123 | 3 | 0.12 | 25.66 | + | 2.21E-04 | 4.12E-02 |
| Positive regulation of cellular amide metabolic process | 133 | 3 | 0.13 | 23.73 | + | 2.77E-04 | 4.76E-02 |
| Response to tumor necrosis factor | 218 | 4 | 0.21 | 19.30 | + | 5.10E-05 | 1.53E-02 |
| Response to chemical | 4323 | 12 | 4.11 | 2.92 | + | 1.35E-04 | 3.02E-02 |
| Striated muscle tissue development | 289 | 4 | 0.27 | 14.56 | + | 1.49E-04 | 3.07E-02 |
| Muscle tissue development | 302 | 4 | 0.29 | 13.94 | + | 1.76E-04 | 3.44E-02 |