Table 2.

Bone mineral density change among patients with schizophrenia and healthy individuals.

	Controls	Non-clozapine antipsychotics	Clozapine	P value
DEXA Z score, overall	(N = 44)	(N = 69)	(N = 42)
Baseline, mean (SD)	0.28 (1.09)	−0.28 (1.14)	0.38 (1.45)	0.008
Endpoint, mean (SD)	0.42 (1.08)	−0.44 (0.96)	0.41 (1.49)	<0.001‡
Difference, mean (SD)	0.16 (0.47)	−0.16 (0.66)	0.03 (0.64)	0.015‡
DEXA Z score, 1 year follow up		(N = 48)	(N = 29)
Baseline, mean (SD)	—	−0.54 (1.10)	0.16 (1.49)	0.017
Endpoint, mean (SD)	—	−0.68 (0.88)	0.09 (1.47)	0.006
Difference, mean (SD)	—	−0.13 (0.56)	−0.08 (0.70)	0.808‡
DEXA Z score, 3 year follow up	(N = 44)	(N = 22)	(N = 13)
Baseline, mean (SD)	0.28 (1.09)	0.28 (1.15)	0.88 (1.29)	0.228
Endpoint, mean (SD)	0.42 (1.08)	0.09 (0.93)	1.13 (1.29)	0.052‡
Difference, mean (SD)	0.16 (0.47)	−0.21 (0.87)	0.25 (0.41)	0.039‡

^‡Mann-Whitney U test, for variables with non-normal distributions.