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. 2019 Mar 1;10:136. doi: 10.3389/fgene.2019.00136

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Copyright © 2019 Nel, Mulder, Europa and Heckmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Outline of analysis approaches applied to whole genome sequencing data. (A) Single variant association analysis. (B) Gene-based association analysis. (C) HLA region association analysis. ^∗ skeletal muscle expression data used for tissue-based prioritization since extraocular muscle data not available. Extreme phenotype refers to individuals with either severe EOM weakness (OP-MG cases) or no EOM weakness (MG controls). WGS, whole genome sequencing. WES, whole exome sequencing. MHC, major histocompatibility complex.