Table 2.

Top 7 genes (based on GTEx skeletal muscle expression data, TPM > 20) with the muscle-specific function of their encoded proteins.

Gene	Function of encoded protein in skeletal muscle
MKNK2	Increased expression in muscle atrophy1 Downstream inhibitor of IGF1/Akt/mTOR hypertrophy signaling2
AKT1S1	Subunit of mTORC1 multi-protein complex
SH3BGR	Critical for sarcomere formation in striated muscle tissues3 Higher expression in mouse EOM compared to limb fibroblasts4
MYL12B	Myosin regulatory light chain which maintains the integrity of myosin I and II5
PPP1R12C	Encodes a subunit of myosin phosphatase which dephosphorylates myosin II6
PPP1R2	Binds to the catalytic subunit of protein phosphatase 1, a subunit of myosin phosphatase
ZFP36L2	RNA-binding protein which is downregulated during satellite cell activation7

¹Hu et al., 2012; ²Egerman and Glass, 2014; ³Jang et al., 2015; ⁴Kusner et al., 2010; ⁵Park et al., 2011; ⁶Ito et al., 2004; ⁷Galloway et al., 2016.