Table 3.
Frequency of HLA-DPA1 and HLA-DPB1 alleles and rs9277534 A > G in OP-MG and control MG subgroups and population controls.
| HLA-DP alleles | OP-MG freq n = 15∗ | Control MG freq n = 10∗ | p-value OP-MG vs. control MG | African control freq1 n = 48 | Caucasian control freq1 n = 75 | p-value African vs. Caucasian control |
|---|---|---|---|---|---|---|
| HLA-DPA1∗01:03 | 15 (0.50) | 3 (0.15) | p = 0.009 | 30 (0.31) | 115 (0.77) | p < 1 × 10−7 |
| HLA-DPA1∗02:01 | 3 (0.10) | 9 (0.45) | p = 0.007 | 23 (0.24) | 26 (0.17) | 0.242 |
| HLA-DPB1∗105:01 (low expression2) | 7 (0.39) | 0 | p = 0.009 | 25 (0.26) | 2 (0.01) | p < 1 × 10−7 |
| HLA-DPB1 rs9277534 A > G (high expression3) | 9 (0.30) | 12 (0.60) | p = 0.04 | 789 (0.60) | 317 (0.32) | p < 1 × 10−7 |
1Goldfein, 2017; 2Schöne et al., 2018; 3Thomas et al., 2012. ∗For HLA-DPB1, allele assignment was ambiguous for 6 OP-MG and 3 control MG individuals and these samples were excluded from the analysis.