Table 4.
Stepwise selection of the logistic regression analysis including the demographics, (A) First model – Model A, tested on the whole study population without tobacco variable; (B) Second model – Model B tested on the study population with tobacco variable available. Variables significant at p = 0.05 are in bold and underlined. Ethnicity: White British was taken as a reference group. TCC – terminal complement complex; C1inh – C1 inhibitor; FB – Factor B; FH – Factor H; FHR125 – Factor H related proteins 1, 2, and 5; CR1 – complement receptor 1; CRP – C-reactive protein; OR – odds ratio; CI – confidence interval.
| Variables | p-Value | logOR (95% CI) |
|---|---|---|
| A | ||
| Sex (male) | 0.051 | 0.81 (− 0.004; 1.62) |
| Age | 0.01 | − 0.04 (− 0.08; − 0.01) |
| Ethnicity: white British | n/a | n/a |
| Ethnicity: mixed | 0.46 | − 0.63 (− 2.31; 1.05) |
| Ethnicity: white other | 0.15 | 0.92 (− 0.34; 2.17) |
| Ethnicity: various Asian | 0.64 | 0.36 (− 1.14; 1.86) |
| Ethnicity: black Caribbean | 0.01 | 1.81 (0.38; 3.24) |
| Ethnicity: black African | 0.004 | 2.40 (0.76; 4.03) |
| Ethnicity: no information | 0.24 | 0.84 (− 0.55; 2.23) |
| TCC | 0.001 | − 0.05 (− 0.08; − 0.02) |
| CRP | 0.19 | 0.06 (− 0.03; 0.15) |
| B | ||
| Sex (male) | 0.001 | 2.55 (1.07; 4.03) |
| Ethnicity: white British | n/a | |
| Ethnicity: mixed | 0.33 | − 1.35 (− 4.05; 1.35) |
| Ethnicity: white other | 0.97 | − 0.03 (− 1.90; 1.84) |
| Ethnicity: various Asian | 0.13 | 1.97 (− 0.57; 4.50) |
| Ethnicity: black Caribbean | 0.02 | 2.98 (0.43; 5.53) |
| Ethnicity: black African | 0.01 | 2.92 (0.78; 5.07) |
| Ethnicity: no information | 0.11 | 1.98 (− 0.44; 4.40) |
| Tobacco | 0.0003 | 2.81 (1.30; 4.33) |
| CR1 | 0.16 | − 86.98 (− 207.87; 33.93) |
| TCC | 0.098 | − 0.04 (− 0.09; 0.01) |
| C3 | 0.02 | − 0.0003 (− 0.0005; − 0.00005) |
| C4 | 0.01 | − 0.009 (− 0.01; − 0.0024) |
| C5 | 0.09 | − 0.01 (− 0.03; 0.002) |
| C1inh | 0.08 | − 0.02(− 0.03; 0.002) |
| FHR125 | 0.08 | 0.12 (− 0.02; 0.26) |