Figure 3.
Blood Biochemistry Test and Pathological Examination of Mice Xenografted with Human Tumors after Treatment with miRT-CVBs
H1299 cells (5 × 106) were transplanted s.c. into BALB/c nude mice; then vehicle control or indicated viruses were inoculated at 5 × 106 TCID50 2 days after transplantation. 5-CVBs (A and C), 3-CVBs (B and D), WT-CVB, or vehicle (A and B) was inoculated. Blood samples were collected at 2 days post-inoculation, and serum ALT, AST, LDH, and amylase levels were measured. Data represent means ± SD of eight or nine mice in each group. *p < 0.05; **p < 0.01; ***p < 0.001 versus control group (Tukey’s test); ††p < 0.01 5a-CVB versus 5c-CVB group (Tukey’s test). (C and D) Representative pathological images of pancreas. Magnification: 10× + 2× zoom. Scale bars, 100 μM. All experiments were repeated twice.