Figure 6.
Low Toxicity of 53a-CVB Treatment in an Immunocompetent Mouse with Lung Cancer
(A) Representative images of mouse lung cancer TC-1 cells inoculated with indicated viruses at an MOI of 10−2 to 1. The cytotoxicity of each virus was determined at 72 h post-infection. (B) Blood biochemistry test of an immunocompetent mouse bearing TC-1 cells. C57BL/6J mice were injected with indicated CVBs or vehicle controls 2 days after syngeneic TC-1 cell transplantation. Mouse serum samples were measured for ALT, AST, LDH, and amylase. Data represent means ± SD (n = 4/group). **p < 0.005; ***p < 0.001 versus control group (Tukey’s test). (C) Pathological images of the pancreas of mice injected with vehicle control, WT-CVB, 5a-CVB, 3a-CVB, or 53a-CVB. Original magnification ×20. Scale bars, 100 μM.