Table 1.
Relative weights of lung, heart and right kidney of Hannover Sprague-Dawley (HanSD) and Ren-2 transgenic rats (TGR) subjected to sham operation (non-MI) or myocardial infarction (MI) and treated with epoxyeicosatrienoic acid analog (EET-A) or soluble epoxide hydrolase inhibitor (c-AUCB), given alone or combined, for 5 weeks since 24 h after MI.
| n | Heart/BW (mg/g) | Lungs/BW (mg/g) | Kidney/BW (mg/g) | |
|---|---|---|---|---|
| HanSD | ||||
| Sham (non-MI) | 8 | 2.71 ± 0.14 | 2.94 ± 0.07 | 3.20 ± 0.07 |
| MI | 11 | 3.23 ± 0.14† | 7.04 ± 0.82† | 3.17 ± 0.15 |
| MI + EET-A | 14 | 3.03 ± 0.09 | 4.84 ± 0.64 | 3.43 ± 0.06 |
| MI + c-AUCB | 10 | 3.10 ± 0.10 | 6.63 ± 1.28 | 3.44 ± 0.09 |
| MI + EET-A + c-AUCB | 14 | 3.00 ± 0.05 | 4.78 ± 0.75 | 3.46 ± 0.04 |
| TGR | ||||
| Sham (non-MI) | 8 | 3.22 ± 0.11 | 3.05 ± 0.13 | 3.57 ± 0.10 |
| MI | 8 | 3.44 ± 0.11 | 6.82 ± 0.59† | 3.11 ± 0.09† |
| MI + EET-A | 8 | 3.19 ± 0.08 | 6.46 ± 0.97 | 3.19 ± 0.04 |
| MI + c-AUCB | 10 | 3.19 ± 0.14 | 6.93 ± 0.74 | 3.14 ± 0.09 |
| MI + EET-A + c-AUCB | 6 | 3.11 ± 0.11 | 7.55 ± 1.29 | 3.07 ± 0.04 |
BW, body weight; n, number of animals. Values are means ± SEM. †P < 0.05 MI vs. corresponding Sham (non-MI) group.