Table 3.

Meta-analyses included for maintenance of clinical remission in ulcerative colitis

Study	Intervention	Comparator	Follow-up	n	Maintenance of clinical remission, RR (95%CI)	Quality of evidence
Wang et al[27]	MTX	Placebo	36 wk	32	RR 0.64 (0.28-1.45)1	Low
	MTX	5-ASA	76 wk	9	RR 1.12 (0.06-20.71)2	Very low
	MTX	6-MP	76 wk	18	RR 0.22 (0.03-1.45)2	Very low

¹Maintenance of remission defined as a Mayo Clinic score of < 3 and off steroids.

² Maintenance of remission defined as relapse within 76 wk (defined as 7 or more in the Mayo Clinic Score). 5-ASA: 5-aminosalicylic acid; 6-MP: 6-mercaptopurine; CI: Confidence interval; MTX: Methotrexate; n: Number of patients; RR: Risk ratio.