Table 3.
Main results of the pooled odds ratios in meta-analysis for the association between ADIPOQ polymorphisms and gestational diabetes mellitus
| SNP | N |
Sample size |
Allelic model |
Dominant model |
Recessive model |
||||
| Case | Control | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | ||
| +45T/G | |||||||||
| Total | 10 | 1024 | 1059 | 1.45 (1.26-1.67) | 0.000a | 1.50 (1.25-1.79) | 0.000a | 2.00 (1.42-2.84) | 0.000a |
| Subgroup | |||||||||
| Ethnicity | |||||||||
| Asian | 8 | 945 | 890 | 1.47 (1.27-1.70) | 0.000a | 1.54 (1.27-1.85) | 0.000a | 2.00 (1.43-2.85) | 0.000a |
| SA | 1 | 79 | 169 | 1.21 (0.68-2.41) | 0.510 | 1.13 (0.59-2.15) | 0.710 | 2.18 (0.43-11.07) | 0.350 |
| +276G/T | |||||||||
| Total | 5 | 590 | 595 | 0.88 (0.74-1.05) | 0.158 | 0.91 (0.65-1.26) | 0.561 | 0.82 (0.64-1.05) | 0.118 |
| -11377C/G | |||||||||
| Total | 5 | 722 | 791 | 0.96 (0.72-1.26) | 0.750 | 1.00 (0.73-1.37) | 0.980 | 0.90 (0.61-1.32) | 0.570 |
| Subgroup | |||||||||
| Ethnicity | |||||||||
| Asian | 2 | 309 | 286 | 1.04 (0.77-1.41) | 0.800 | 1.09 (0.79-1.50) | 0.600 | 0.97 (0.51-1.86) | 0.930 |
| SA | 1 | 79 | 168 | 0.80 (0.50-1.29) | 0.360 | 0.77 (0.44-1.36) | 0.370 | 0.81 (0.28-2.34) | 0.690 |
| European | 2 | 334 | 337 | 0.94 (0.45-1.96) | 0.870 | 1.00 (0.42-2.33) | 0.990 | 0.87 (0.51-1.49) | 0.610 |
a
P < 0.01. ADIPOQ: Adiponectin; SA: South American; GDM: Gestational diabetes mellitus; SNP: Single nucleotide polymorphism; N: Number of studies; OR: Odds ratio; CI: Confidence interval; NA: Not assessable.