Table III.
Phenotypic symptoms of 175 patients recruited to the UK-GAPP study with HMB of unknown aetiology. Types of bleeding symptoms were assessed using the ISTH-BAT and the percentage of patients suffering from a platelet defect or no platelet defect using lumiaggregometry are listed. Statistical analysis was performed using ordinary two-way ANOVA with Sidak’s multiple comparisons test. P-values are listed, no statistical significance was noted (P ≥ 0.05).
| Type of bleeding | Patients with platelet defect (n = 82) |
Patients with no platelet defect (n = 93) |
Percentage of total patients with bleeding tendencies | P-value |
|---|---|---|---|---|
| Heavy menstrual bleeding | 82 | 93 | 100 | 0.9898 |
| Cutaneous bleeding | 73 | 77 | 85.7 | >0.9999 |
| Oral cavity bleeding | 66 | 69 | 77.1 | >0.9999 |
| Bleeding from minor wounds | 55 | 57 | 64.0 | >0.9999 |
| Bleeding after tooth/teeth extraction | 55 | 48 | 58.9 | >0.9999 |
| Epistaxis | 48 | 45 | 53.1 | >0.9999 |
| Post-partum hemorrhage | 38 | 45 | 47.4 | 0.9998 |
| Bleeding after surgery/major Trauma | 44 | 33 | 44 | 0.9898 |
| Gastrointestinal bleeding | 25 | 28 | 30.3 | >0.9999 |
| Hematuria | 18 | 25 | 24.6 | 0.9998 |
| Muscle hematomas or hemarthrosis (spontaneous) | 14 | 10 | 13.7 | >0.9999 |
| Other bleeding1 | 66 | 38 | 59.4 | 0.2343 |
1other bleeding episodes includes: venipuncture and ovulation bleeding, conjunctival hemorrhage or excessive bleeding following or venipuncture. Overall some patients had > 1 other bleeding complaint