Table 2.
Multivariable cox proportional hazard model of association between chronic rhinosinusitis and Sjögren’s syndrome.
| Variables | HR | 95% CI | p-value |
|---|---|---|---|
| Main model * | 2.51 | (2.22–2.84) | <0.001 |
| Additional covariates † | |||
| Main model+GERD | 2.52 | (2.22–2.86) | <0.001 |
| Main model+COPD | 2.51 | (2.22–2.84) | <0.001 |
| Main model+Asthma | 2.51 | (2.22–2.84) | <0.001 |
| Main model+DM | 2.48 | (2.20–2.81) | <0.001 |
| Main model+HT | 2.50 | (2.21–2.83) | <0.001 |
| Main model+SLE | 2.57 | (2.25–2.94) | <0.001 |
| Main model+RA | 2.69 | (2.36–3.08) | <0.001 |
| Subgroup effects | |||
| GERD | |||
| Yes | 2.21 | (1.73–2.83) | <0.001 |
| No | 2.64 | (2.28–3.05) | <0.001 |
| COPD | |||
| Yes | 2.16 | (1.66–2.82) | <0.001 |
| No | 2.60 | (2.26–2.99) | <0.001 |
| Asthma | |||
| Yes | 2.18 | (1.63–2.90) | <0.001 |
| No | 2.58 | (2.25–2.96) | <0.001 |
| DM | |||
| Yes | 2.71 | (1.99–3.68) | <0.001 |
| No | 2.47 | (2.15–2.82) | <0.001 |
| HT | |||
| Yes | 2.74 | (2.25–3.33) | <0.001 |
| No | 2.35 | (2.01–2.76) | <0.001 |
| SLE | |||
| Yes | 4.71 | (0.65–33.9) | 0.124 |
| No | 2.56 | (2.24–2.92) | <0.001 |
| RA | |||
| Yes | 2.25 | (1.38–3.68) | 0.001 |
| No | 2.71 | (2.36–3.11) | <0.001 |
Abbreviations: HR, hazard ratio; CI, confidence interval; Abbreviations: SS, Sjögren’s syndrome; NTD, New Taiwan dollar; NSD, nasal septal deviation; GERD, gastroesophageal reflux disease; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; HT, hypertension; SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; CRS, chronic rhinosinusitis. * Main model is stratified by sex, age, urbanization, income, rhinitis, and nasal septal deviation. † The models are adjusted for covariates in the main model, as well as each additional listed covariate.