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. 2019 Feb 6;11(2):188. doi: 10.3390/cancers11020188

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cx37 (de)phospho-isoforms form HChs that transition between multiple open states. (A) Representative current traces and all associated points histogram with visible HCh transitions of variable size recorded from isolated cells in the presence of 1 mM [Ca²⁺]. V_m= +25 mV for all traces. (B) HCh transition amplitude histograms of Cx37-isoforms. Cx37-WT: N = 16, n = 1044; -S321D: N = 24, n = 1943; -S328D: N = 8, n = 1620; -S328A: N = 11, n = 1692; -S275D: N = 25, n = 1071. Note change in range of event frequency values for Cx37-S275D as HCh transitions were less frequent due to long dwell times in the closed state.