Figure 2.

(A) miR-141 in endothelial cells: The downregulation of miR-141 and the subsequent upregulation of ICAM-1 results in increased extravasation of neutrophils, which release ROS and amplify necrosis. Hence miR-141 protects endothelial cells in Ischemia-Reperfusion injury. (B) Effects of miR-141 on cardiomyocytes: In cardiomyocytes, the upregulation of miR-141 leads to an increase in ROS by increasing the expression of ROS-generating agents such as NOX-4 and TXNIP, as well as decreasing the activity of antioxidants such as catalase and SOD. In addition, miR-141 silences ICAM-1 expression, hence the induction of apoptosis. ICAM-1: Intercellular Adhesion Molecule 1; NOX-4: NADPH Oxidase 4; TXNIP: Thioredoxin-Interacting Protein; SOD: Superoxide Dismutase.