Table 2.
Genome-wide associations of 29 SNPs with intracranial aneurysm.
| Gene | Chr. | SNP | Class | M/m a | MAF b | OR c | L95 c | U95 c | P c | Power d |
|---|---|---|---|---|---|---|---|---|---|---|
| PRDM2 | 1p36.21 | rs61775135 | intron | C/A | 0.16/0.41 | 0.32 | 0.23 | 0.43 | 3.6E-13 | 0.42 |
| GBA | 1q22 | rs75822236 | R535H | C/T | 0.33/0.01 | 161.40 | 53.86 | 483.60 | 1.1E-19 | 1.00 |
| FMO4 | 1q24.3 | rs3737926 | F281F | C/T | 0.16/0.37 | 0.36 | 0.27 | 0.50 | 1.8E-10 | 0.32 |
| RNF144A | 2p25.1 | rs6741819 | intron | C/T | 0.13/0.37 | 0.25 | 0.18 | 0.36 | 4.0E-14 | 0.72 |
| FLJ45964 | 2q37.3 | rs59626274 | stop-gained | C/T | 0.13/0.36 | 0.26 | 0.18 | 0.37 | 5.8E-14 | 0.71 |
| LINC01237 | 2q37.3 | rs78458145 | intron | G/A | 0.17/0.4 | 0.24 | 0.17 | 0.35 | 3.1E-15 | 0.68 |
| SPCS3 | 4q34.2 | rs17688188 | intergenic | G/A | 0.11/0.33 | 0.27 | 0.19 | 0.38 | 6.0E-13 | 0.73 |
| TCF24 | 8q13.1 | rs112859779 | G141S | C/T | 0.1/0.33 | 0.19 | 0.12 | 0.28 | 3.3E-16 | 0.94 |
| C9orf92 | 9p22.3 | rs12350582 | intergenic | A/G | 0.33/0.18 | 2.43 | 1.79 | 3.31 | 1.5E-08 | 0.20 |
| LINGO2 | 9p21.1 | rs56942085 | intron | G/A | 0.1/0.03 | 6.11 | 3.20 | 11.64 | 3.9E-08 | 0.78 |
| TMOD1 | 9q22.33 | rs1052270 | intron | C/T | 0.27/0.42 | 0.41 | 0.30 | 0.56 | 2.7E-08 | 0.15 |
| SUSD1 | 9q31.3 | rs79461840 | intron | T/C | 0.13/0.02 | 6.92 | 3.55 | 13.49 | 1.4E-08 | 0.65 |
| LINC00474 | 9q33.1 | rs4979583 | intergenic | C/T | 0.41/0.24 | 2.45 | 1.82 | 3.31 | 4.6E-09 | 0.24 |
| OLFML2A | 9q33.3 | rs79134766 | A208T | G/A | 0.07/0.37 | 0.14 | 0.09 | 0.21 | 1.7E-19 | 0.96 |
| MYEOV | 11q13.3 | rs76855873 | intron | C/T | 0.16/0.37 | 0.33 | 0.24 | 0.46 | 1.2E-11 | 0.43 |
| ARHGAP32 | 11q24.3 | rs371331393 | stop-gained | G/A | 0.32/0.02 | 43.57 | 21.84 | 86.95 | 9.3E-27 | 1.00 |
| CD163L1 | 12p13.31 | rs138525217 | splice-site | C/T | 0.31/0.01 | 75.98 | 32.13 | 179.70 | 6.2E-23 | 1.00 |
| SLC2A14 | 12p13.31 | rs118107419 | intron | C/A | 0.14/0.39 | 0.25 | 0.17 | 0.35 | 1.4E-14 | 0.67 |
| DRAM1 | 12q23.2 | rs7964241 e | intergenic | A/G | 0.35/0.21 | 2.49 | 1.81 | 3.42 | 2.0E-08 | 0.25 |
| CUL4A | 13q34 | rs74115822 | intergenic | G/A | 0.19/0.03 | 6.25 | 3.58 | 10.90 | 1.1E-10 | 0.80 |
| LINC02130 | 16p13.12 | rs11646803 | intron | C/T | 0.28/0.48 | 0.45 | 0.35 | 0.58 | 4.8E-10 | 0.06 |
| LOC102724084 | 16q23.2 | rs75861150 | intron | T/C | 0.02/0.16 | 0.14 | 0.07 | 0.28 | 1.3E-08 | 1.00 |
| SCARF1 | 17p13.3 | rs3744644 | E639D | G/C | 0.18/0.35 | 0.39 | 0.28 | 0.54 | 6.0E-09 | 0.26 |
| MINK1 | 17p13.2 | rs72835045 | intron | G/A | 0.11/0.33 | 0.25 | 0.17 | 0.37 | 1.7E-12 | 0.79 |
| SLC47A1 | 17p11.2 | rs2440154 e | intron | G/A | 0.28/0.13 | 2.67 | 1.90 | 3.75 | 1.4E-08 | 0.26 |
| NAPA-AS1 | 19q13.32 | rs55800589 | intron | G/C | 0.32/0.4 | 0.38 | 0.29 | 0.49 | 3.4E-13 | 0.23 |
| DSCAM | 21q22.2 | rs727333 | intron | C/A | 0.14/0.38 | 0.26 | 0.18 | 0.36 | 3.7E-14 | 0.69 |
| LRRC3 | 21q22.3 | rs116969723 | P63P | G/A | 0.11/0.35 | 0.24 | 0.16 | 0.34 | 3.8E-15 | 0.81 |
| SLC5A4-AS1 | 22q12.3 | rs117398778 | intron | T/C | 0.21/0.07 | 3.74 | 2.43 | 5.75 | 2.0E-09 | 0.56 |
Chr. chromosome; L95, lower 95% confidence interval; OR, odds ratio; U95, upper 95% confidence interval. a M/m, major/minor allele type; b MAF, minor allele frequency in case (left) and control (right); c OR, 95% confidence interval, and p-value were estimated in the multivariate logistic regression model after adjustment for age, sex, hypertension, diabetes, hyperlipidemia, cigarette smoking, and four principal components; d The statistical power for each SNP was estimated by performing the web-based Genetic Power Calculator (http://zzz.bwh.harvard.edu/gpc/cc2.html) using parameters, such as 5% prevalence of intracranial aneurysm, MAF in control, OR under an additive model, D-prime 0.8, 1:1.18 case-control ratio (296 controls/250 cases = 1.18), and type 1 error rate of 5e-8 (genome-wide significance threshold); e One SNP shown in a pairwise linkage disequilibrium (LD, r2 < 0.8): rs7964241 and rs56168082 (r2 = 0.81); rs2440154 and rs2289668 (r2 = 1.0).