Table 3.
Gene enrichment functional analysis using candidate genes for susceptibility to intracranial aneurysms (p < 0.05).
| Biological Function a | P b | FDR, % b | Gene, N | Gene Set |
|---|---|---|---|---|
| Biological process in ontology | ||||
| GO: 0030154~cell differentiation | 0.0117 | 16.8 | 10 |
EDNRA, LINGO2, CUL4A, SLC2A14, MINK1, SCARF1, BOLL, DSCAM, TMOD1, GBA |
| GO: 0031175~neuron projection development |
0.0120 | 17.2 | 5 | LINGO2, MINK1, SCARF1, DSCAM, GBA |
| GO: 0048468~cell development | 0.0181 | 24.8 | 7 | EDNRA, LINGO2, MINK1, SCARF1, DSCAM, TMOD1, GBA |
| GO: 0016358~dendrite development | 0.0192 | 26.1 | 3 | MINK1, SCARF1, DSCAM |
| GO: 0048869~cellular developmental process |
0.0209 | 28.1 | 10 |
EDNRA, LINGO2, CUL4A, SLC2A14, MINK1, SCARF1, BOLL, DSCAM, TMOD1, GBA |
| GO: 0048666~neuron development | 0.0210 | 28.3 | 5 | LINGO2, MINK1, SCARF1, DSCAM, GBA |
| GO: 0007275~multicellular organism development |
0.0260 | 33.8 | 11 |
EDNRA, LINGO2, CUL4A, SLC2A14, MINK1, PRDM2, SCARF1, BOLL, DSCAM, TMOD1, GBA |
| GO: 0051130~positive regulation of cellular component organization |
0.0406 | 47.7 | 5 | LINGO2, CUL4A, SCARF1, DSCAM, GBA |
| GO: 0030182~neuron differentiation | 0.0454 | 51.6 | 5 | LINGO2, MINK1, SCARF1, DSCAM, GBA |
| Cellular component in ontology | ||||
| GO:0044425~membrane part | 0.0088 | 9.7 | 15 |
FMO4, RNF144A, LINGO2, EDNRA, LRRC3, ARHGAP32, CD163L1, SLC2A14, SUSD1, SPCS3, MINK1, SLC47A1, DRAM1, SCARF1, DSCAM |
| GO:0016021~integral component of membrane |
0.0160 | 16.9 | 13 | FMO4, RNF144A, LINGO2, EDNRA, LRRC3, CD163L1, SLC2A14, SUSD1, SPCS3, SLC47A1, DRAM1, SCARF1, DSCAM |
| GO:0031224~intrinsic component of membrane |
0.0186 | 19.4 | 13 | FMO4, RNF144A, LINGO2, EDNRA, LRRC3, CD163L1, SLC2A14, SUSD1, SPCS3, SLC47A1, DRAM1, SCARF1, DSCAM |
| GO:0016020~membrane | 0.0205 | 21.1 | 17 |
RNF144A, LRRC3, SUSD1, SLC2A14, MINK1, SLC47A1, SCARF1, FMO4, EDNRA, LINGO2, ARHGAP32, CD163L1, SPCS3, DRAM1, DSCAM, TMOD1, GBA |
FDR, false discovery rate; GO, gene ontology. a Functional categories in gene ontology; b Fisher’s exact p-value and FDR of each biological function were estimated by DAVID v.6.8 program.