Domain	Animals Selection	Index Test	Reference Standard	Flow and Timing
Signaling question (yes, no or unclear)	Does the origin of animals come from company?	Is the origin of bacterial cells certified ATCC?	Is the used reference standard appropriated for the study?	Is the imaging time appropriated for the study?
		Is it a standardized infection model?
		Can the radiopharmaceutical synthesis be a source of bias? (QCs, AS)		Could the difference interval time between bacteria injection and radiopharmaceutical administration be a source of bias?
		Were further in vitro, in vivo, ex-vivo tests performed to support main results?
Risk of bias (high, low or unclear)	Could the selection of animals have introduced bias?	Could the methodology of experiments have introduced bias?	Could the reference standard or its interpretation have introduced bias?	Could the study flow have introduced bias?
Concerns about applicability (high, low, or unclear)	Are there concerns that the included animals do not match the review question?	Are there concerns that the index test or its interpretation differ from the review question?	Are there concerns that the target condition as defined by the reference standard does not match the review question?	-