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. 2019 Feb 2;11(2):175. doi: 10.3390/cancers11020175

Figure 5.

Figure 5

Connexin43-expressing H125 cells exhibit increased cytotoxicity and reduced ability to develop resistance to cisplatin. (A,B) The cisplatin concentration–response curves indicated approximately five-fold greater drug toxicity in H125-CX43 cells (mean ± S.D., n = 4 replicate experiments). (C) A longer duration of exposure was required to develop resistance to 2 µg/mL cisplatin in two separate trials with each cell line. (D) Western blot of Cx43 in cisplatin-naïve (H125-CX43) and resistant cells (CPR-1 and CPR-2); band densities were normalized to tubulin loading control and to H125-CX43 (* p < 0.01 compared to H125-CX43, one-sample t-test, mean ± S.D., n = 4 replicate experiments).